 | | Offense | | QB: Shaun Hill | | RB: Frank Gore | | FB: M. Norris | | WR1: D. Jackson | | WR2: A. Battle | | TE: V. Davis | | RT: Joe Staley | | RG: David Baas | | C: E. Heitmann | | LG: L. Allen | | LT: A. Snyder |
| Defense | | LE: B. Young | | DT: | | NT: A. Franklin | | RE: M. Douglas | | SLB: | | MLB: | | WLB: | | LCB: N. Clements | | RCB: W. Harris | | SS: M. M. Lewis | | FS: Mark Roman |
|
| | Offense | | QB: T. Collins | | RB: C. Portis | | FB: M. Sellers | | WR1: S. Moss | | WR2: A. Randle E | | TE: C. Cooley | | RT: S. Heyer | | RG: J. Fabini | | C: C. Rabach | | LG: P. Kendall | | LT: C. Samuels |
| Defense | | LE: P. Daniels | | DT: | | NT: | | RE: A. Carter | | SLB: M. Washingt | | MLB: L. Fletcher | | WLB: R. Godfrey | | LCB: S. Springs | | RCB: Fred Smoot | | SS: L. Landry | | FS: R. Doughty |
|
|
| |
 | | Sack Leaders | Sacks |
| Young | 6.5 |
| Willis | 4.0 |
| Banta-Cain | 3.5 |
| Douglas | 3.0 |
|
| Rushing | Att | Yards | Avg | TDs |
| Frank Gore | 260 | 1102 | 4.2 | 5 |
| Maurice Hicks | 21 | 117 | 5.6 | 1 |
| Shaun Hill | 12 | 14 | 1.2 | 1 |
| Arnaz Battle | 4 | 4 | 1.0 | 1 |
|
| Receiving | Rec | Yards | Avg | TDs |
| Arnaz Battle | 50 | 600 | 12.0 | 5 |
| Vernon Davis | 52 | 509 | 9.8 | 4 |
| Darrell Jackson | 46 | 497 | 10.8 | 3 |
| Frank Gore | 53 | 436 | 8.2 | 1 |
|
| Interceptions | Ints | Yards | Avg | TDs |
| Nate Clements | 4 | 74 | 18.5 | 0 |
| Walt Harris | 4 | 42 | 10.5 | 0 |
| Michael Lewis | 2 | 18 | 9.0 | 0 |
| Derek Smith | 1 | 4 | 4.0 | 0 |
|
| Passing | Com | Yards | Pct | TDs | Ints | Rating |
| T. Dilfer | 113 | 1166 | 51.6 | 7 | 12 | 55.1 |
| Alex Smith | 94 | 914 | 48.7 | 2 | 4 | 57.2 |
| Shaun Hill | 54 | 501 | 68.4 | 5 | 1 | 101.3 |
|
| |
 | | Sack Leaders | Sacks |
| Carter | 10.5 |
| Washington | 5.0 |
| Wilson | 4.0 |
| McIntosh | 3.0 |
|
| Rushing | Att | Yards | Avg | TDs |
| Clinton Portis | 325 | 1262 | 3.9 | 11 |
| Mike Sellers | 26 | 78 | 3.0 | 2 |
| Ladell Betts | 93 | 335 | 3.6 | 1 |
| Jason Campbell | 36 | 185 | 5.0 | 1 |
|
| Receiving | Rec | Yards | Avg | TDs |
| Chris Cooley | 66 | 786 | 11.9 | 8 |
| Santana Moss | 61 | 808 | 13.2 | 3 |
| James Thrash | 9 | 107 | 11.9 | 2 |
| Antwaan Randle El | 51 | 728 | 14.3 | 1 |
|
| Interceptions | Ints | Yards | Avg | TDs |
| Carlos Rogers | 1 | 61 | 61.0 | 1 |
| London Fletcher | 3 | 36 | 12.0 | 1 |
| Sean Taylor | 5 | 98 | 19.6 | 0 |
| Shawn Springs | 4 | 63 | 15.8 | 0 |
|
| Passing | Com | Yards | Pct | TDs | Ints | Rating |
| J. Campbell | 250 | 2700 | 60.0 | 12 | 11 | 77.6 |
| T. Collins | 67 | 888 | 63.8 | 5 | 0 | 106.4 |
| A. Randle El | 1 | 19 | 50.0 | 0 | 0 | 83.3 |
|
| |
 | | No. | Player | Pos | Ht | Wt | DOB | EXP | College |
| 64 | Baas,David | G | 6-4 | 331 | 9/28/82 | 4 | Michigan |
| 47 | Bajema,Billy | TE | 6-4 | 258 | 10/31/82 | 4 | Oklahoma Sta. |
| 43 | Baker,Lewis | S | 6-3 | 203 | 10/12/84 | R | Oklahoma |
| 67 | Balmer,K. | DT | 6-5 | 295 | 10/15/86 | R | North Caroli. |
| 95 | Banta-Cain,T. | LB | 6-2 | 280 | 8/28/80 | 6 | California |
| 83 | Battle,Arnaz | WR | 6-1 | 213 | 2/22/80 | 6 | Notre Dame |
| 78 | Booker,John | G | 6-4 | 313 | 9/23/86 | R | San Jose Sta. |
| 25 | Brown,Tarell | CB | 5-10 | 194 | 1/6/85 | 2 | Texas |
| 88 | Bruce,Isaac | WR | 6-0 | 188 | 11/10/72 | 15 | Memphis |
| 33 | Clayton,T. | RB | 5-11 | 225 | 4/26/84 | 1 | Kansas State |
| 22 | Clements,Nate | CB | 6-0 | 215 | 12/12/79 | 8 | Ohio State |
| 76 | Cohen,Joe | DT | 6-2 | 315 | 6/6/84 | 2 | Florida |
| 81 | Colvin,Cam | WR | 6-3 | 210 | 6/6/83 | R | Oregon |
| 40 | Curry,Markus | CB | 5-11 | 181 | 4/7/81 | 1 | Michigan |
| 60 | Curry,Walter | DT | 6-4 | 241 | 6/18/81 | 1 | Albany State |
| 85 | Davis,Vernon | TE | 6-3 | 253 | 1/31/84 | 3 | Maryland |
| 60 | De La Puente,B. | G | 6-4 | 302 | 5/13/85 | R | California |
| 63 | Duckett,D. | DT | 6-6 | 318 | 1/21/81 | 4 | East Carolin. |
| 78 | Ellison,A. | DE | 6-3 | 318 | 9/29/81 | 3 | Missouri |
| 93 | Fields,Ronald | DT | 6-2 | 321 | 9/13/81 | 4 | Mississippi . |
| 49 | Finley,J.J. | TE | 6-6 | 254 | 1/30/85 | R | Oklahoma |
| 29 | Foster,D. | RB | 6-0 | 222 | 1/10/82 | 7 | U-C-L-A |
| 92 | Franklin,A. | DT | 6-1 | 334 | 9/27/80 | 6 | Tennessee |
| 38 | Goldson,D. | S | 6-2 | 208 | 9/18/84 | 2 | Washington |
| 21 | Gore,Frank | RB | 5-9 | 223 | 5/14/83 | 4 | Miami-Florid. |
| 57 | Grant,Larry | LB | 6-1 | 235 | 2/16/85 | R | Ohio State |
| 54 | Green,R. | LB | 6-2 | 270 | 4/26/82 | 5 | Central Miss. |
| 55 | Haley,Dennis | LB | 6-1 | 247 | 2/18/82 | 3 | Virginia |
| 98 | Haralson,P. | DE | 6-0 | 260 | 1/24/84 | 3 | Tennessee |
| 27 | Harris,Walt | CB | 5-11 | 199 | 8/10/74 | 13 | Mississippi . |
| 66 | Heitmann,Eric | C | 6-3 | 318 | 2/24/80 | 7 | Stanford |
| 13 | Hill,Shaun | QB | 6-3 | 235 | 1/9/80 | 7 | Maryland |
| 89 | Hill,Jason | WR | 6-0 | 204 | 2/20/85 | 2 | Washington S. |
| 62 | Holmes,Louis | DE | 6-6 | 265 | 2/24/85 | R | Arizona |
| 23 | Hudson,Marcus | CB | 6-2 | 198 | 11/15/82 | 3 | NC State |
| 75 | Jennings,J. | T | 6-3 | 325 | 11/21/77 | 8 | Georgia |
| 86 | Jennings,B. | TE | 6-5 | 228 | 10/14/76 | 9 | Arizona Stat. |
| 82 | Johnson,B. | WR | 6-3 | 214 | 3/7/81 | 6 | Penn State |
| 15 | Jordan,Robert | WR | 5-11 | 171 | 1/29/86 | R | California |
| 45 | Keasey,Zak | RB | 6-0 | 245 | 3/19/82 | 2 | Princeton |
| 99 | Lawson,Manny | LB | 6-5 | 247 | 7/3/84 | 3 | NC State |
| 4 | Lee,Andy | P | 6-0 | 185 | 8/11/82 | 5 | Pittsburgh |
| 18 | Lelie,Ashley | WR | 6-3 | 193 | 2/16/80 | 7 | Hawaii |
| 32 | Lewis,Michael | S | 6-1 | 226 | 4/29/80 | 7 | Colorado |
| 28 | Lewis,Keith | S | 6-0 | 228 | 10/20/81 | 5 | Oregon |
| 91 | McDonald,Ray | DL | 6-3 | 282 | 9/20/84 | 2 | Florida |
| 56 | Moore,Brandon | LB | 6-1 | 255 | 1/16/79 | 7 | Oklahoma |
| 58 | Moore,Jay | LB | 6-4 | 270 | 8/16/83 | 2 | Nebraska |
| 84 | Morgan,Josh | WR | 6-0 | 219 | 6/20/85 | R | Virginia Tec. |
| 6 | Nedney,Joe | K | 6-5 | 233 | 3/22/73 | 13 | San Jose Sta. |
| 44 | Norris,Moran | FB | 6-1 | 252 | 6/16/78 | 8 | Kansas |
| 96 | Oliver,Melvin | DE | 6-3 | 282 | 7/25/83 | 3 | L-S-U |
| 7 | Olson,Drew | QB | 6-2 | 222 | 4/6/83 | 1 | U-C-L-A |
| 14 | OSullivan,J. | QB | 6-2 | 227 | 8/25/79 | 6 | UC-Davis |
| 41 | Parker,D.J. | S | 6-0 | 198 | 4/18/85 | R | Virginia Tec. |
| 0 | Pruneda,R. | T | 6-6 | 317 | 1/25/83 | 1 | Monterrey Te. |
| 19 | Rabb,Jerard | WR | 6-2 | 199 | 8/19/84 | 1 | Boise State |
| 62 | Rachal,Chilo | G | 6-4 | 319 | 3/15/86 | R | U-S-C |
| 61 | Ramsey,LaJuan | DT | 6-3 | 300 | 3/19/84 | 3 | U-S-C |
| 67 | Reuber,Alan | T | 6-6 | 307 | 1/26/81 | 2 | Texas A&M |
| 50 | Richardson,S. | LB | 6-1 | 248 | 4/18/85 | R | Tennessee St. |
| 24 | Robinson,M. | RB | 6-1 | 228 | 2/6/83 | 3 | Penn State |
| 26 | Roman,Mark | S | 5-11 | 203 | 3/26/77 | 9 | L-S-U |
| 20 | Rossum,Allen | CB | 5-8 | 175 | 10/22/75 | 10 | Notre Dame |
| 2 | Schmitt,Ricky | P | 6-3 | 200 | 8/17/85 | 1 | Shepherd |
| 94 | Smith,Justin | DE | 6-4 | 275 | 9/30/79 | 8 | Missouri |
| 11 | Smith,Alex | QB | 6-4 | 212 | 5/7/84 | 4 | Utah |
| 31 | Smith,Reggie | CB | 6-1 | 199 | 9/13/86 | R | Oklahoma |
| 68 | Snyder,Adam | G | 6-6 | 326 | 1/30/82 | 4 | Oregon |
| 90 | Sopoaga,Isaac | DT | 6-2 | 325 | 9/4/81 | 5 | Hawaii |
| 36 | Spencer,S. | CB | 6-1 | 181 | 2/22/82 | 5 | Pittsburgh |
| 74 | Staley,Joe | OT | 6-5 | 306 | 8/30/84 | 2 | Central Mich. |
| 30 | Strickland,D. | CB | 5-10 | 187 | 11/24/80 | 6 | Colorado |
| 77 | Terry,Jeb | G | 6-5 | 311 | 4/10/81 | 4 | North Caroli. |
| 51 | Thomas,D. | LB | 6-2 | 241 | 9/2/80 | 5 | Auburn |
| 0 | Toledo,Joe | T | 6-5 | 330 | 10/20/82 | 2 | Washington |
| 53 | Ulbrich,Jeff | LB | 6-0 | 240 | 2/17/77 | 9 | Hawaii |
| 46 | Walker,D. | WR | 6-0 | 244 | 8/12/84 | 3 | Central Miss. |
| 48 | Wallace,C. | TE | 6-3 | 258 | 4/26/82 | 1 | Auburn |
| 65 | Wallace,Cody | C | 6-4 | 290 | 11/26/84 | R | Texas A&M |
| 52 | Willis,P. | LB | 6-1 | 242 | 1/25/85 | 2 | Ole Miss |
| 69 | Wragge,Tony | G | 6-4 | 320 | 8/14/79 | 4 | New Mexico S. |
| 15 | Zeigler,D. | WR | 6-2 | 181 | 10/11/84 | 1 | Baylor |
| |
 | | No. | Player | Pos | Ht | Wt | DOB | EXP | College |
| 67 | Albright,E. | LS | 6-5 | 257 | 5/1/71 | 14 | North Caroli. |
| 79 | Alexander,L. | DT | 6-1 | 300 | 5/31/83 | 2 | California |
| 91 | Askew,M. | DT | 6-5 | 302 | 7/1/82 | 2 | Michigan Sta. |
| 46 | Betts,Ladell | RB | 5-11 | 225 | 8/27/79 | 6 | Iowa |
| 54 | Blades,H.B. | LB | 5-10 | 236 | 9/30/84 | 1 | Pittsburgh |
| 73 | Boschetti,R. | DT | 6-4 | 311 | 10/7/81 | 4 | U-C-L-A |
| 5 | Brennan,Colt | QB | 6-2 | 201 | 8/16/83 | R | Hawaii |
| 14 | Brooks,Durant | P | 6-0 | 204 | 5/29/86 | R | Georgia Tech |
| 36 | Broughton,N. | FB | 5-11 | 255 | 11/4/82 | 3 | Citadel |
| 78 | Brown,Kerry | OL | 6-5 | 305 | 6/19/85 | R | Appalachian . |
| 90 | Buzbee,Alex | DE | 6-3 | 265 | 11/27/85 | 1 | Georgetown |
| 50 | Campbell,K. | LB | 6-3 | 232 | 7/23/80 | 6 | Bowling Gree. |
| 17 | Campbell,J. | QB | 6-5 | 233 | 12/31/81 | 3 | Auburn |
| 99 | Carter,Andre | DE | 6-4 | 252 | 5/12/79 | 7 | California |
| 31 | Cartwright,R. | RB | 5-8 | 218 | 12/3/79 | 6 | Kansas State |
| 62 | Clark,Devin | OL | 6-3 | 350 | 5/22/86 | R | New Mexico |
| 15 | Collins,Todd | QB | 6-4 | 228 | 11/5/71 | 13 | Michigan |
| 47 | Cooley,Chris | TE | 6-3 | 249 | 7/11/82 | 4 | Utah State |
| 72 | Crummey,A. | OL | 6-5 | 301 | 10/22/84 | R | Maryland |
| 93 | Daniels,P. | DE | 6-4 | 276 | 3/4/73 | 12 | Georgia |
| 72 | Davis,Tommy | DE | 6-2 | 257 | 10/18/82 | 1 | North Caroli. |
| 86 | Davis,Fred | TE | 6-3 | 247 | 1/15/86 | R | U-S-C |
| 51 | DeVan,Kyle | C | 6-2 | 300 | 2/10/85 | R | Oregon State |
| 10 | Devine,Derek | QB | 6-3 | 222 | 7/19/84 | 1 | Marshall |
| 37 | Doughty,Reed | S | 6-1 | 209 | 11/4/82 | 2 | Northern Col. |
| 88 | Ecker,Tyler | TE | 6-6 | 246 | 4/18/82 | 1 | Michigan |
| 92 | Evans,D. | DE | 6-3 | 275 | 9/3/79 | 7 | Georgia |
| 69 | Fabini,Jason | OL | 6-7 | 309 | 8/25/74 | 10 | Cincinnati |
| 59 | Fletcher,L. | LB | 5-10 | 245 | 5/19/75 | 10 | John Carroll |
| 39 | Fox,Vernon | S | 5-10 | 203 | 10/9/79 | 6 | Fresno State |
| 4 | Frost,Derrick | P | 6-4 | 208 | 11/25/80 | 4 | Northern Iow. |
| 84 | Gant,Horace | WR | 6-3 | 218 | 4/7/85 | R | Saint Olaf C. |
| 56 | Gatewood,C. | LB | 6-2 | 248 | 5/18/85 | R | Vanderbilt |
| 68 | Geisinger,J. | OL | 6-3 | 322 | 5/24/82 | 3 | Vanderbilt |
| 64 | Golston,K. | DT | 6-4 | 320 | 5/30/83 | 2 | Georgia |
| 85 | Goode,Jason | TE | 6-3 | 238 | 9/13/86 | R | Maryland |
| 96 | Griffin,C. | DT | 6-3 | 311 | 12/3/76 | 8 | Alabama |
| 74 | Heyer,Stephon | T | 6-6 | 320 | 1/16/84 | 1 | Maryland |
| 3 | Hollenbach,S. | QB | 6-4 | 214 | 9/9/83 | 1 | Maryland |
| 38 | Holt,Cedrick | CB | 5-11 | 171 | 12/30/83 | 1 | North Caroli. |
| 48 | Horton,Chris | S | 6-1 | 216 | 12/29/84 | R | U-C-L-A |
| 97 | Huntley,Kevin | DE | 6-7 | 270 | 4/8/82 | 2 | Kansas State |
| 98 | Jackson,Rob | DE | 6-4 | 259 | 11/3/85 | R | Kansas State |
| 78 | James,Erasmus | DE | 6-4 | 266 | 11/4/82 | 3 | Wisconsin |
| 76 | Jansen,Jon | T | 6-6 | 297 | 1/28/76 | 9 | Michigan |
| 12 | Kelly,Malcolm | WR | 6-3 | 219 | 12/30/86 | R | Oklahoma |
| 66 | Kendall,Pete | G | 6-5 | 292 | 7/9/73 | 12 | Boston Colle. |
| 30 | Landry,LaRon | S | 6-0 | 213 | 10/14/84 | 1 | L-S-U |
| 80 | Mann,Maurice | WR | 6-1 | 190 | 9/14/82 | 1 | Nevada |
| 23 | Mason,Marcus | RB | 5-9 | 215 | 6/23/84 | 1 | Youngstown S. |
| 52 | McIntosh,R. | LB | 6-2 | 232 | 11/15/82 | 2 | Miami-Florid. |
| 16 | McMullen,B. | WR | 6-4 | 215 | 3/8/80 | 4 | Virginia |
| 19 | Mix,Anthony | WR | 6-5 | 235 | 1/20/83 | 2 | Auburn |
| 94 | Montgomery,A. | DT | 6-6 | 315 | 3/8/84 | 2 | Minnesota |
| 41 | Moore,Kareem | S | 5-11 | 213 | 8/13/84 | R | Nicholls Sta. |
| 89 | Moss,Santana | WR | 5-10 | 200 | 6/1/79 | 7 | Miami-Florid. |
| 26 | Portis,C. | RB | 5-11 | 223 | 9/1/81 | 6 | Miami-Florid. |
| 61 | Rabach,Casey | C | 6-4 | 296 | 9/24/77 | 7 | Wisconsin |
| 82 | Randle El,A. | WR | 5-10 | 190 | 8/17/79 | 6 | Indiana |
| 40 | Richardson,M. | CB | 5-11 | 194 | 6/30/85 | R | Arkansas |
| 75 | Rinehart,Chad | OL | 6-5 | 311 | 5/4/85 | R | Northern Iow. |
| 22 | Rogers,Carlos | CB | 6-0 | 194 | 7/2/81 | 3 | Auburn |
| 60 | Samuels,Chris | T | 6-5 | 310 | 7/28/77 | 8 | Alabama |
| 40 | Schmitt,Pete | FB | 6-1 | 252 | 10/14/84 | 1 | Wisconsin-Wh. |
| 36 | Schweigert,S. | S | 6-2 | 210 | 6/21/81 | 5 | Purdue |
| 45 | Sellers,Mike | FB | 6-3 | 284 | 7/21/75 | 8 | Walla Walla . |
| 35 | Shelton,Eric | RB | 6-1 | 246 | 6/23/83 | 2 | Louisville |
| 58 | Sinclair,Matt | LB | 6-2 | 245 | 7/24/82 | 1 | Illinois |
| 74 | Smith,Dorian | DE | 6-1 | 264 | 1/1/85 | R | Oregon State |
| 27 | Smoot,Fred | CB | 5-11 | 192 | 4/17/79 | 7 | Mississippi . |
| 24 | Springs,Shawn | CB | 6-0 | 200 | 3/11/75 | 11 | Ohio State |
| 6 | Suisham,Shaun | K | 6-0 | 205 | 12/29/81 | 3 | Bowling Gree. |
| 77 | Thomas,Randy | G | 6-5 | 317 | 1/19/76 | 9 | Mississippi . |
| 11 | Thomas,Devin | WR | 6-1 | 218 | 11/15/86 | R | Michigan Sta. |
| 83 | Thrash,James | WR | 6-0 | 204 | 4/28/75 | 11 | Missouri Sou. |
| 18 | Toler,Burl | WR | 6-2 | 185 | 4/7/83 | 1 | California |
| 29 | Torrence,L. | CB | 6-0 | 179 | 1/4/82 | 3 | Stanford |
| 20 | Tryon,Justin | CB | 5-9 | 190 | 5/29/84 | R | Arizona Stat. |
| 51 | Verdun-Wheeler,D. | LB | 6-2 | 244 | 3/16/85 | 1 | Georgia |
| 71 | Wade,Todd | OL | 6-8 | 314 | 10/30/76 | 8 | Ole Miss |
| 55 | Wallace,Rian | LB | 6-3 | 243 | 5/24/82 | 2 | Temple |
| 53 | Washington,M. | LB | 6-3 | 248 | 9/17/77 | 8 | Auburn |
| 63 | Washington,T. | OL | 6-3 | 320 | 4/20/83 | 1 | Florida |
| 34 | Westbrook,B. | CB | 5-10 | 194 | 12/26/85 | 1 | Salisbury |
| 95 | Wilson,Chris | DE | 6-4 | 240 | 7/10/82 | 1 | Northwood |
| 87 | Yoder,Todd | TE | 6-4 | 253 | 3/18/78 | 8 | Vanderbilt |
| |
 | | San Francisco | Pos | Date | Status | Type |
| Derek Smith | LB | 12/30 | Out | shoulder |
| C.J. Brewer | WR | 8/26 | IR | knee |
| Shaun Hill | QB | 12/30 | Out | back |
| Arnaz Battle | WR | 12/30 | Probable | ankle |
| Frank Gore | RB | 12/30 | Probable | ankle |
| Jeff Ulbrich | LB | 12/30 | Probable | ankle |
| B.J. Tucker | CB | 7/31 | IR | pectoral |
| Melvin Oliver | DE | 8/26 | PUP | knee |
| Jonas Jennings | T | 11/5 | IR | ankle |
| Alex Smith | QB | 12/12 | IR | right shoulder |
| Trent Dilfer | QB | 12/30 | Out | concussion |
| Marcus Hudson | CB | 12/30 | Out | knee |
| M. Robinson | RB | 12/30 | Probable | shoulder |
| S. Spencer | CB | 12/30 | Out | quadriceps |
| Justin Smiley | G | 11/8 | IR | shoulder |
| Manny Lawson | LB | 9/21 | IR | knee |
| Jay Moore | LB | 9/1 | IR | ankle |
| Jason Hill | WR | 12/30 | Out | groin |
| Joe Cohen | DT | 9/1 | IR | knee |
| Tarell Brown | CB | 12/30 | Out | leg |
| | Washington | Pos | Date | Status | Type |
| Ross Tucker | OL | 8/27 | IR | neck |
| Jason Campbell | QB | 1/5/2008 | Out | knee |
| Randy Thomas | G | 12/13 | IR | elbow |
| N. Broughton | FB | 7/31 | IR | knee |
| Steven Harris | WR | 7/31 | IR | knee |
| James Thrash | WR | 1/5/2008 | Out | ankle |
| Rocky McIntosh | LB | 12/19 | IR | knee |
| Brandon Lloyd | WR | 11/15 | IR | collarbone |
| Mike Pucillo | C | 12/27 | IR | back |
| Jon Jansen | T | 9/11 | IR | ankle |
| Carlos Rogers | CB | 10/30 | IR | knee |
| Tyler Ecker | TE | 9/1 | IR | undisclosed |
| Jason McAddley | WR | 8/27 | IR | hamstring |
| Mike Espy | WR | 8/20 | IR | knee |
| |
| |
 | | AFC | COMP | YDS | TD | INT | RATING |
| T.Brady, NEP | 398 | 4806 | 50 | 8 | 117.2 |
| Roethlisberger, PIT | 264 | 3154 | 32 | 11 | 104.1 |
| D.Garrard, JAC | 208 | 2509 | 18 | 3 | 102.2 |
| | NFC | COMP | YDS | TD | INT | RATING |
| T.Romo, DAL | 335 | 4211 | 36 | 19 | 97.4 |
| B.Favre, GBP | 356 | 4155 | 28 | 15 | 95.7 |
| J.Garcia, TAM | 209 | 2440 | 13 | 4 | 94.6 |
| | AFC | ATT | YDS | AVG | TD |
| LaDainian Tomlinson, SDC | 315 | 1474 | 4.7 | 15 |
| Willie Parker, PIT | 321 | 1316 | 4.1 | 2 |
| Jamal Lewis, CLE | 298 | 1304 | 4.4 | 9 |
| | NFC | ATT | YDS | AVG | TD |
| Adrian Peterson, MIN | 238 | 1341 | 5.6 | 12 |
| Brian Westbrook, PHI | 278 | 1333 | 4.8 | 7 |
| Clinton Portis, WAS | 325 | 1262 | 3.9 | 11 |
| | AFC | REC | YDS | AVG | TD |
| T.J. Houshmandzadeh, CIN | 112 | 1143 | 10.2 | 12 |
| Wes Welker, NEP | 112 | 1175 | 10.5 | 8 |
| Reggie Wayne, IND | 104 | 1510 | 14.5 | 10 |
| | NFC | REC | YDS | AVG | TD |
| Larry Fitzgerald, ARI | 100 | 1409 | 14.1 | 10 |
| Marques Colston, NOS | 98 | 1202 | 12.3 | 11 |
| Jason Witten, DAL | 96 | 1145 | 11.9 | 7 |
| | AFC | SACKS |
| Jared Allen, KAN | 15.5 |
| Mario Williams, HOU | 14 |
| Elvis Dumervil, DEN | 12.5 |
| | NFC | SACKS |
| Patrick Kerney, SEA | 14.5 |
| DeMarcus Ware, DAL | 14 |
| Osi Umenyiora, NYG | 13 |
| | AFC | INT | YDS | TD |
| Thomas Howard, OAK | 6 | 172 | 2 |
| Vincent Fuller, TEN | 2 | 137 | 2 |
| Antonio Cromartie, SDC | 10 | 144 | 1 |
| | NFC | INT | YDS | TD |
| Antrel Rolle, ARI | 5 | 231 | 3 |
| Roderick Hood, ARI | 5 | 196 | 2 |
| Mike McKenzie, NOS | 3 | 161 | 2 |
| | AFC | TACKLES |
| D.J. Williams, DEN | 106 |
| DeMeco Ryans, HOU | 98 |
| Kirk Morrison, OAK | 95 |
| | NFC | TACKLES |
| Patrick Willis, SFX | 136 |
| Jon Beason, CAR | 104 |
| Nick Barnett, GBP | 102 |
|
| | |